Enzymic modulator to reduce lactic acid
accumulation and delay muscle fatigue
Dichloro-acetic acid 120 μg/mL
Sodium gluconate 250 mg/mL
Lactanase contains dichloroacetic acid, which is an activator of the
enzyme pyruvate dehydrogenase. This enzyme plays a central role
in the process of lactic acid production during hard work.
Supplementation with dichloroacetic acid (DCA) results in activation
of the enzyme pyruvate dehydrogenase, leading to a reduction
in the rate of lactic acid production and accumulation in muscles.
Elevated plasma lactate levels result in a reduction in pH which
contributes to muscle fatigue and decreased muscle performance.
Supplementation with DCA has been shown to reduce lactic acid
accumulation during exercise, and produce a significant delay in
The pathogenesis of Exertional Rhabdomyolysis (“Tying Up”) in
horses is related to lactic acidosis during exercise, and associated
low muscle pH.
Sodium bicarbonate and dimethylglycine (DMG), which may help
to reduce lactic acid accumulation during exercise, have been
used to assist in the prevention of Tying Up in horses. Similarly,
DCA (Lactanase) results in a reduction in the rate of lactate
accumulation, and a delay in the onset of muscle fatigue.
To help reduce the incidence of Tying Up by reducing the build-up of
lactic acid in muscle cells.
DOSAGE AND ADMINISTRATION
Administer intravenously via a catheter or dilute in 1 L saline before
Adult Horse: 20-40 mL
Administer once weekly for 4 weeks then discontinue for 4 weeks
before repeating the course.
Take care to avoid leakage from the vein. Lactanase is highly irritant
if given outside the vein. Avoid accidental contact with mucous
membranes or eyes (avoid accidental spillage or spray).
Meat Withholding Period: NOT TO BE USED in horses that may be
slaughtered for human consumption.
100 mL sterile glass multidose vial.
Store below 25˚C (Air Conditioning). Protect from light.
By Veterinary Prescription
Within Australia, Lactanase is a Prescription Only Remedy,
manufactured under Permit, and available for sale only to
registered veterinary surgeons.
L-carnitine, Physine, Green Amino Powder, DMG, Tripart,
Tridenosen, AMP-5, Untie.